(AP) - Virginia Health Commissioner Karen Remley has resigned over the state's controversial new abortion clinic regulations.

Remley submitted her resignation to Gov. Bob McDonnell Thursday. Her resignation is effective immediately.

Remley said in the letter that issues surrounding the development and enforcement of the clinic regulations have created an environment that compromises her ability to fulfill her duties. She did not elaborate.

The state Board of Health last month adopted regulations that require existing abortion clinics in Virginia to meet the same construction standards as new hospitals. Abortion-rights advocates argued the strict standards could force most clinics out of business.

Gov. McDonnell issued a statement praising Remley's service.

“As Commissioner she served two governors from two different parties, and all the citizens of Virginia, with constant professionalism, intellect and dedication,” McDonnell wrote. “She was a tireless public servant, and we will miss her in the Administration. I wish Dr. Remley the very best moving forward, and know she will continue to play a leading role in healthcare in Virginia in the years ahead.”