UPDATE: 9:55PM
Frederick County dispatchers say, there is now a second accident, on the same side of the Interstate, just North of the first crash.
They say, initial reports are that no one is injured in the second crash.
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Frederick County dispatchers tell TV3 that deputies are on the scene of a crash just South of Clearbrook on Interstate 81.
They say, initial reports indicate one person is out of the vehicle.
Expect delays heading South, in this area, as deputies investigate the crash.